Constant Fatigue Despite Enough Sleep – When Metabolism May Play a Role
Persistent fatigue despite adequate sleep is common in modern working life. Metabolic and nutritional factors are frequently overlooked as underlying contributors.
Common Metabolic Causes
- Iron deficiency – even without anaemia, low ferritin impairs cellular energy production
- Vitamin D3 deficiency – affects mitochondrial function and serotonin regulation
- Vitamin B12 deficiency – essential for neurological function
- Thyroid dysfunction – even subclinical hypothyroidism causes significant fatigue
- Insulin resistance – impaired glucose uptake leaves cells energy-deprived
- Magnesium deficiency – involved in over 300 enzymatic reactions
Why These Are Often Missed
Standard blood panels frequently omit ferritin, free thyroid hormones, vitamin D, and magnesium. At the Zentrum für Prävention und Ernährung Berlin, persistent fatigue is evaluated in the full metabolic context to identify root causes rather than manage symptoms.
Reviewed by Olha Bezuhla, Nutrition Expert · Zentrum für Prävention und Ernährung, Berlin
